Nozaki-Hiyama耦合
Nozaki-Hiyama-Kishi反应

卤化物和醛之间的这种偶联是铬诱导的氧化还原反应。一个关键优势是对醛的高化学选择性。缺点是使用过量的有毒铬盐。

较新的方法允许使用催化量的铬（II），其通过用锰还原或通过电化学还原而再生。

Nozaki-Hiyama-Kishi耦合的机理

催化反应：

Recent Literature

Asymmetric Catalysis of Nozaki-Hiyama Allylation and Methallylation with A New Tridentate Bis(oxazolinyl)carbazole Ligand
M. Inoue, T. Suzuki, M. Nakada, J. Am. Chem. Soc., 2003, 125, 1140-1141.

A Highly Enantioselective Catalyst for the Asymmetric Nozaki-Hiyama-Kishi Reaction of Allylic and Vinylic Halides
A. Berkessel, D. Menche, C. A. Sklorz, M. Schroeder, I. Paterson, Angew. Chem. Int. Ed., 2003, 42, 1032-1035.

Stereochemical Diversity in Chiral Ligand Design: Discovery and Optimization of Catalysts for the Enantioselective Addition of Allylic Halides to Aldehydes
J.-Y. Lee, J. J. Miller, S. S: Hamilton, M. S. Sigman, Org. Lett., 2005, 7, 1837-1839.